|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
SUMO-1 may be useful as a novel target for therapy in colon cancer as well as a clinical indicator for tumor aggressiveness.
|
23640307 |
2013 |
|
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
In this study, we genotyped SUMO1 and UBC9 polymorphisms in 147 non-small-cell lung cancer (NSCLC) treated with irinotecan chemotherapy to investigate the association between genotypes and tumor response rate.
|
19859084 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
A newly cloned gene named wild-type p53-activated fragment 1 (WAF1; also known as p21, Pic-1, Cip-1, or SDI1) is directly regulated by p53 and can itself suppress tumor cell growth in culture.
|
7949134 |
1994 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our data demonstrate a molecular mechanism whereby SUMO1 modification is required for PTEN tumour suppressor function by controlling PTEN membrane association and regulation of the phosphatidylinositol-3 kinase/AKT pathway.
|
22713753 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Moreover, PIASy-mediated SUMO1 modification induces VHL oligomerization and abrogates its inhibitory function on tumor cell growth, migration and clonogenicity.
|
20300531 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The soft-agar colony formation, migration, vasculogenic mimicry (VM) and three-dimensional (3D) cell culture assays were performed to detect the phenotypes of tumor cells in vitro, and the xenograft tumor model in mice was conducted to verify that SUMO1 modification of KHSRP regulated tumorigenesis in vivo.
|
29020972 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
An increasing amount of data has indicated that the lncRNA small ubiquitin-like modifier 1 (SUMO1) pseudogene 3 (SUMO1P3) has been involved in various types of human cancer.
|
30333879 |
2018 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
By the co-expression of Cx43 and SUMO1 in cancer stem cells, the gap junction intercellular communication (GJIC) of liver cancer stem cells was obviously improved.
|
29393359 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1.
|
31578236 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry was used to detect an association between SUMO1 and NF-κB in the cancer and adjacent tissues of 168 patients with lung cancer.
|
30393970 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
An increasing amount of data has indicated that the lncRNA small ubiquitin-like modifier 1 (SUMO1) pseudogene 3 (SUMO1P3) has been involved in various types of human cancer.
|
30333879 |
2018 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry was used to detect an association between SUMO1 and NF-κB in the cancer and adjacent tissues of 168 patients with lung cancer.
|
30393970 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1.
|
31578236 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
By the co-expression of Cx43 and SUMO1 in cancer stem cells, the gap junction intercellular communication (GJIC) of liver cancer stem cells was obviously improved.
|
29393359 |
2018 |
|
Cytomegalovirus Infections
|
0.030 |
Biomarker
|
group |
LHGDN |
NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.
|
18836734 |
2008 |
|
Cytomegalovirus Infections
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We generated primary human fibroblasts stably expressing FLAG-SUMO-1 or FLAG-SUMO-3 and analysed the SUMOylation pattern after HCMV infection or isolated IE1 expression.
|
23407422 |
2013 |
|
Cytomegalovirus Infections
|
0.030 |
Biomarker
|
group |
LHGDN |
SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease.
|
14637113 |
2003 |
|
Neurodegenerative Disorders
|
0.020 |
Biomarker
|
group |
LHGDN |
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.
|
16464864 |
2006 |
|
Neurodegenerative Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
A key member of the sentrin/small ubiquitin-like modifier (SUMO)-specific protease (SENP) family, SENP2 has been shown to implicate embryonic development, fatty acid metabolism, atherosclerosis, and neurodegenerative diseases.
|
29969578 |
2019 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Interestingly, the main clinical phenotype reported for a disruption of the SUMO1 locus is the common birth defect cleft lip and palate.
|
28197921 |
2017 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Although the majority of these pathways are known to be involved with immune response, we found several interesting new interactions such as the SUMO1 pathway that might have a role in bacterial infections.
|
24086587 |
2013 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.
|
23078246 |
2013 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The SUMO1-APP transgenics displayed normal APP processing but, at later ages, exhibited increased insoluble Aβ and plaque density accompanied by increased dendritic spine loss, more pronounced synaptic and cognitive deficits.
|
29217476 |
2018 |
|
Atrial Septal Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Sequence analysis of DNA from newborn screening blood spots revealed a single 16 bp substitution in the SUMO-1 regulatory promoter of a patient displaying both oral-facial clefts and ASDs.
|
21563299 |
2011 |
|
Ventricular Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
Both hetero- and homozygous SUMO-1 knockout mice exhibited ASDs and VSDs with high mortality rates, which were rescued by cardiac reexpression of the SUMO-1 transgene.
|
21563299 |
2011 |